Age-Related Decline in Testosterone 03:12

Age-related decline in testosterone in males, termed hypogonadism, occurs due to testicular failure (primary) and disruption in the hypothalamus-pituitary (secondary).

Risk factors for hypogonadism include type 2 diabetes, obesity, renal failure, HIV, hypertension, chronic obstructive pulmonary disease (COPD), taking glucocorticoid (steroids), opioid or antipsychotic medication therapy, and environmental exposure to mercury, lead, and pesticides.

Lifestyle factors affecting hypogonadism include stress management, adequate physical activity, healthy eating, adequate sleep, alcohol intake, and smoking.